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CAS号：158021-47-7

品牌：AdipoGen   货号：AG-CN2-0013-M001

·免疫刺激药。

·天然杀伤性T（NKT）细胞的有效刺激剂。

·人和小鼠NKT细胞中与脂质结合的MHC I类蛋白CD1d的特异性配体。

·防止LPS引起的电击。

·有效的抗肿瘤化合物。

名称：α-半乳糖神经酰胺 NK细胞激活剂 AG-CN2-0013-M001
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品牌货号产品名称规格目录价
AdipoGenAG-CN2-0013-M001

alpha-Galactosylceramide

α-半乳糖神经酰胺，NK细胞激活剂

1 mg

3120

产品说明书：

AG_CN2_0013_alpha_GalCer_Solubilization_Protocol_Update_2014.pdf

AG-CN2-0013-alpha-Galactosylceramide.pdf


More Information
Product Details
Synonymsα-Gal-Cer; KRN7000
Product TypeChemical


Properties

Formula

C50H99NO9

MW858.3
CAS158021-47-7
Source/Host ChemicalsSynthetic. Originally isolated from the marine sponge Agelas mauritianus.
Purity Chemicals≥96% (NMR)
AppearanceOff-white solid.
SolubilitySoluble in pyridine. Solubilization in Tween20 or PBS for cell culture use see online protocol.
IdentityIdentity determined by 1H-NMR.
DeclarationManufactured by AdipoGen. Not sold in Japan.
InChi KeyLSUQVAFARUJTHS-ABBGRRHVSA-N
Smiles[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](COC1OC(CO)C(O)C(O)C1O)NC(=O)CC#CC#CC#CC#CC#CC#CC#CC#CC#CC#CC#CC#C


Shipping and Handling

ShippingBLUE ICE
Short Term Storage+4°C
Long Term Storage-20°C
Handling AdviceAliquot into glass vials.
Use/StabilityStable for at least 2 years after receipt when stored at -20°C.


·参考文献

  1. Synthesis of alpha-, beta-monoglycosylceramides and four diastereomers of an alpha-galactosylceramide: M. Morita, et al.; Bioorg. Med. Chem. Lett. 5, 699 (1995)
  2. Immunostimulatory and antitumor activities of monoglycosylceramides having various sugar moieties: K. Motoki, et al.; Biol. Pharm. Bull. 18, 1487 (1995)
  3. Immunostimulatory activities of monoglycosylated alpha-D-pyranosylceramides: A. Uchimura, et al.; Bioorg. Med. Chem. 5, 2245 (1997)
  4. Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein: Fujii S, et al.; J. Exp. Med. 198, 267 (2003)
  5. Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides: K.O. Yu, et al.; PNAS 102, 3383 (2005)
  6. A phase I study of alpha-galactosylceramide (KRN7000)-pulsed dendritic cells in patients with advanced and recurrent non-small cell lung cancer: A. Ishikawa, et al.; Clin. Cancer Res. 11, 1910 (2005)
  7. Pivotal advance: alpha-galactosylceramide induces protection against lipopolysaccharide-induced shock: G. Sireci, et al.; J. Leukoc. Biol. 81, 607 (2007)
  8. α-Galactosylceramide activates antitumor immunity against liver tumor: T. Tatsumi, et al.; Hepatol. Res. 41, 160 (2011)
  9. Deletion of CD1d in adipocytes aggravates adipose tissue inflammation and insulin resistance in obesity: J.Y. Huh, et al.; Diabetes 66, 835 (2017)



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